Related Experiment Video
Updated: Jan 31, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
Mid-Left Ventricular Ballooning Variant Takotsubo Syndrome Induced by Treadmill Exercise Stress Testing
1Department of Medicine, Stony Brook University Medical Center, USA.
Insights
Takotsubo cardiomyopathy, or stress-induced cardiomyopathy, mimics heart attacks but lacks blocked arteries. This case highlights a variant triggered by exercise stress testing, showing mid-left ventricular dysfunction.
Area of Science:
- Cardiology
- Cardiovascular Medicine
- Clinical Case Reports
Background:
- Stress-induced cardiomyopathy (Takotsubo cardiomyopathy) mimics myocardial infarction symptoms following stressors.
- Classically presents with transient left ventricular apical systolic dysfunction.
- Diagnosis excludes obstructive coronary artery disease.
Observation:
- A patient presented with symptoms similar to myocardial infarction after treadmill exercise stress testing.
- No obstructive coronary artery disease was identified.
- The patient exhibited mid-left ventricular hypokinesis.
Findings:
- The case demonstrates a variant of takotsubo cardiomyopathy triggered by exercise stress.
- This variant presented with mid-left ventricular hypokinesis, differing from the typical apical ballooning.
- Exercise stress testing can precipitate atypical forms of stress-induced cardiomyopathy.
Implications:
- Highlights the diverse clinical presentations of takotsubo cardiomyopathy.
- Suggests exercise stress testing as a potential trigger for variant forms.
- Emphasizes the importance of considering takotsubo cardiomyopathy in patients with stress-related cardiac dysfunction, even with atypical patterns.
Abstract:
Stress-induced cardiomyopathy, also known as takotsubo cardiomyopathy, presents similar to a myocardial infarction after a physical or emotional stressor but without any evidence of obstructive coronary artery disease. Different patterns of myocardial involvement and several triggering events have been reported, but classically this condition is characterized by a stress-induced transient left ventricular apical systolic dysfunction. We describe a case of treadmill exercise stress testing-triggered variant of takotsubo cardiomyopathy with mid-left ventricular hypokinesis.
Related Concept Videos
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Actin Treadmilling
Histone Variants at the Centromere
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

