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MDAD: A Special Resource for Microbe-Drug Associations
Ya-Zhou Sun1, De-Hong Zhang2, Shu-Bin Cai1
1Department of Computer Science and Technology, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
Frontiers in Cellular and Infection Microbiology
|December 25, 2018
Summary
A new Microbe-Drug Association Database (MDAD) catalogs 5,055 microbe-drug links. This resource aids understanding of microbe-drug interactions for improved drug design and human health.
Area of Science:
- Microbiology
- Pharmacology
- Bioinformatics
Background:
- The human microbiota plays a critical role in health, disease, and behavior.
- Understanding microbe-drug interactions is crucial for drug discovery and therapeutic design.
- Current knowledge on the functional dynamics and interaction mechanisms between microbes and drugs is limited.
Purpose of the Study:
- To develop a comprehensive database of microbe-drug associations.
- To facilitate research into the complex relationships between microbes and pharmaceutical compounds.
- To provide a valuable resource for drug design, disease therapy, and advancing human health.
Main Methods:
- Compiled a database of clinically or experimentally supported microbe-drug associations.
- Collected 5,055 entries, including 1,388 drugs and 180 microbes.
- Integrated data from multiple drug databases and scientific publications.
Main Results:
- Developed the Microbe-Drug Association Database (MDAD).
- MDAD contains 5,055 curated entries linking drugs and microbes.
- Each record includes detailed annotations, drug information (DrugBank), and microbe targets (Uniprot).
Conclusions:
- MDAD serves as a valuable resource for exploring microbe-drug relationships.
- The database supports deeper understanding of drug effects on the human microbiota.
- MDAD can significantly benefit drug design, clinical therapy, and overall human health research.
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