Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Choosing Between z and t Distribution01:25

Choosing Between z and t Distribution

3.6K
The z and the Student t distribution estimate the population mean using the sample mean and standard deviation. However, to decide which distribution to use for a calculation, one needs to determine the sample size, the nature of the distribution, and whether the population standard deviation is known. If the population standard deviation is known and the population is normally distributed, or if the sample size is greater than 30, the z distribution is preferred. The Student t distribution is...
3.6K
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

1.6K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
1.6K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

925
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
925
Inhaled Medications01:23

Inhaled Medications

798
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
798
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

1.6K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
1.6K
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

258
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
258

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study.

The British journal of psychiatry : the journal of mental science·2026
Same author

Advancing the development of diagnostic criteria for clinical depression by scientific strategies.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

Faecal Transplantation for Bipolar Disorder.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2026
Same author

A psychiatrist's best friend - Reflections.

The British journal of psychiatry : the journal of mental science·2026
Same author

Gordon Parker - A tribute to a legendary Australian psychiatrist.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

A further piece of my mind.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026

Related Experiment Video

Updated: Jan 31, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.2K

How to choose an antidepressant medication.

A Bayes1,2, G Parker1,2

  • 1School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.

Acta Psychiatrica Scandinavica
|December 25, 2018
PubMed
Summary
This summary is machine-generated.

Choosing an antidepressant involves assessing depressive subtypes and severity. Personalized antidepressant selection can be improved by matching medication to specific patient profiles and biomarkers for better treatment outcomes.

Keywords:
antidepressantefficacymajor depressive disorderpersonalised medicineprecision medicine

More Related Videos

Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration
07:03

Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration

Published on: February 23, 2017

8.0K
Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
10:43

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Published on: June 27, 2014

20.5K

Related Experiment Videos

Last Updated: Jan 31, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.2K
Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration
07:03

Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration

Published on: February 23, 2017

8.0K
Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
10:43

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Published on: June 27, 2014

20.5K

Area of Science:

  • Psychiatry and Pharmacology
  • Clinical Psychology

Background:

  • Clinical depression management requires effective antidepressant selection.
  • Current antidepressant choice relies on general guidelines, often lacking personalization.

Purpose of the Study:

  • To develop a model for guiding antidepressant medication choice in clinical depression.
  • To integrate patient-specific factors and scientific literature into treatment selection.

Main Methods:

  • A narrative review of antidepressant choice parameters.
  • Synthesis of findings with clinical experience to create a decision-making model.
  • Assessment of patient-specific factors like depressive subtypes, severity, and comorbidities.

Main Results:

  • Precision psychiatry biomarkers currently have limited clinical utility for antidepressant selection.
  • A model is proposed that prioritizes matching antidepressant class to depressive subtypes or symptom clusters.
  • Antidepressant choice can be further refined by severity, personality, comorbidities, and side-effect profiles.

Conclusions:

  • Personalized antidepressant selection can be enhanced by trialing medications in specific depressive subtypes.
  • Combining 'top-down' (subtype-based) and 'bottom-up' (biomarker-based) approaches can optimize antidepressant choice.
  • Future research should focus on testing antidepressant efficacy within defined individual categories for personalized treatment.