Related Experiment Video
Updated: Jan 31, 2026

Preparation of Decellularized Kidney Scaffolds in Rats
Published on: March 18, 2021
Biocompatibility and Immunogenicity of Decellularized Allogeneic Aorta in the Orthotopic Rat Model
Michalis Katsimpoulas1,2, Lucrezia Morticelli3, Ioanna Gontika4
11 Centre of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Impact Statement:
The generation of a small-caliber arterial graft, utilizing a large vessel of a small animal, such as the aorta of the rat or rabbit, for clinical use in the peripheral arterial tree, can widen the options for arterial prostheses. This in vivo study demonstrated the ability of the decellularization protocol that was used to produce a noncytotoxic acellular small-caliber arterial graft, with sufficient biomechanical and biological integrity to withstand the demanding flow and pressure environment of the rat aorta. This work also demonstrated the superiority of the decellularized homograft over its intact counterpart, in terms of lower immunogenicity.
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