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Prospective Plant Based Anticancer Lead Molecules.

Prabhjot Kaur1, Vikas Sharma1

  • 1University Institute of Pharma Sciences, Chandigarh University, National Highway 95, Chandigarh-Ludhiana Highway, Mohali, Punjab-140413, India.

Current Topics in Medicinal Chemistry
|December 25, 2018
PubMed
Summary
This summary is machine-generated.

Natural products offer promising anticancer agents, including terpenoids, flavones, glycosides, and alkaloids. This review explores plant-derived compounds and their structure-activity relationships for novel cancer drug discovery.

Keywords:
AbietaneAnticancerFucoxanthinLead moleculesObovatolPhytoconstituentsTerpenoids.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Cancer is a leading global cause of death, with increasing drug resistance necessitating novel therapeutic strategies.
  • Natural products, particularly phytoconstituents, represent a rich source for identifying potential anticancer lead molecules.
  • Established cancer treatments face challenges like cross-resistance, highlighting the urgent need for new drug candidates.

Purpose of the Study:

  • To review and summarize plant-based anticancer agents derived from natural products.
  • To classify these agents based on their phytochemical nature.
  • To discuss structure-activity relationships (SAR) of selected lead molecules for anticancer drug development.

Main Methods:

  • Literature review of studies on plant-derived anticancer agents.
  • Classification of compounds based on phytochemical classes (terpenoids, flavones, glycosides, alkaloids).
  • Analysis of structure-activity relationships for identified lead molecules.

Main Results:

  • Identification and summarization of various phytoconstituents with anticancer potential.
  • Classification of plant-based anticancer agents according to their chemical structures.
  • Discussion of key SAR points for selected natural product-derived anticancer leads.

Conclusions:

  • Phytoconstituents like terpenoids, flavones, glycosides, and alkaloids are valuable sources for novel anticancer drug discovery.
  • Understanding SAR is crucial for optimizing the efficacy of these plant-based anticancer agents.
  • This review provides a foundation for further research into natural products as anticancer therapeutics.