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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
847
Modelling optimal delivery of bFGF to chronic wounds using ODEs
Johnny Thew1, Pamela Burrage1, Natalie Medlicott2
1School of Mathematical Sciences, Queensland University of Technology, Australia.
Journal of Theoretical Biology
|December 25, 2018
Summary
Optimizing the distribution of basic fibroblast growth factor (bFGF) is crucial for effective chronic wound healing. Prioritizing bound bFGF concentration over minimizing delivered bFGF improves treatment outcomes.
Area of Science:
- Biomedical Engineering
- Mathematical Biology
- Wound Healing Research
Background:
- Chronic wounds pose a significant healthcare burden.
- Effective drug delivery is essential for managing chronic wounds.
- Basic fibroblast growth factor (bFGF) plays a role in wound healing.
Purpose of the Study:
- To develop an ordinary differential equation model for bFGF delivery in chronic wounds.
- To determine optimal bFGF delivery strategies.
- To investigate the impact of the wound's proteolytic environment on bFGF efficacy.
Main Methods:
- An ordinary differential equation model was formulated.
- Optimal control theory was applied to optimize bFGF delivery.
- The objective functional was minimized with respect to the control variable.
- Simulations compared optimal vs. alternative delivery rates.
Main Results:
- Optimizing bound bFGF distribution is more critical than minimizing delivered bFGF quantity.
- Highly proteolytic wound environments can lead to decreased bound bFGF concentrations late in treatment.
- Proteolytic environments increase the cost associated with bFGF delivery.
Conclusions:
- Prioritizing the optimization of bound bFGF concentration is key for effective chronic wound treatment.
- The proteolytic nature of chronic wounds significantly impacts bFGF treatment efficacy and delivery cost.
- Mathematical modeling provides valuable insights for improving drug delivery in chronic wound care.
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