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Prognostic molecular markers in pediatric liver disease - Are there any?

Jon Nielsen1, Vibeke Brix Christensen1, Lise Borgwardt2

  • 1Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|December 25, 2018
PubMed

Insights

Identifying prognostic molecular markers for pediatric liver disease (PLD) is challenging due to limited data. Further research is needed to understand PLD mechanisms and find reliable biomarkers for better patient outcomes.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Molecular Biology

Background:

  • Pediatric liver disease (PLD) causes significant morbidity and hospitalization in children.
  • Prognostic stratification of pediatric patients with liver disease is difficult.
  • Limited understanding of molecular mechanisms hinders the discovery of reliable prognostic biomarkers for PLD.

Purpose of the Study:

  • To systematically review molecular markers with prognostic potential in pediatric liver disease.
  • To identify markers related to survival, liver transplantation (LT), and disease progression/regression.
  • To assess the current evidence level and identify research gaps in PLD biomarker discovery.

Main Methods:

  • Systematic literature search of MEDLINE (PubMed) and Embase (OVID) from August 2007 to August 2017.
  • Selection of studies reporting molecular markers with prognostic relevance in PLD.
  • Inclusion of studies focusing on biliary atresia, non-alcoholic fatty liver disease, viral hepatitis, and LT.

Main Results:

  • Included 23 studies with 898 patients, predominantly small, single-center studies with high bias risk.
  • Identified markers related to morphogenesis, fibrosis, metabolic pathways, and inflammation.
  • Found limited evidence, highlighting the need for further validation of molecular markers in PLD.

Conclusions:

  • Current evidence for molecular prognostic biomarkers in pediatric liver disease is limited and of low quality.
  • Further robust biological and clinical studies are essential to advance molecular insights into PLD.
  • Improved understanding of molecular mechanisms is crucial for developing reliable prognostic tools and improving pediatric liver disease management.

Keywords:
ChildrenDiagnosticsHepatobiliary diseaseOutcome prediction

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