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The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers

Didem Arman1, Secil Ercin2, Sevilay Topcuoğlu3

  • 1Division of Neonatology, Department of Pediatrics, Suleymaniye Maternity and Children's Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.

American Journal of Perinatology
|December 25, 2018
PubMed

Insights

Infants born to mothers with preeclampsia exhibit an altered oxidant-antioxidant balance, with higher oxidative stress index (OSI) levels. Echocardiographic cardiac functions in these infants were not found to be affected by this imbalance.

Area of Science:

  • Neonatal research
  • Maternal-fetal medicine
  • Biochemistry

Background:

  • Preeclampsia poses risks to fetal development.
  • Oxidative stress plays a role in pregnancy complications.
  • Assessing neonatal oxidant-antioxidant status is crucial.

Purpose of the Study:

  • To evaluate global oxidant and antioxidant status in infants of preeclamptic mothers.
  • To investigate the correlation between oxidant status and cardiac function in these infants.

Main Methods:

  • Comparative study of 40 infants born to preeclamptic mothers and 40 controls.
  • Measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) in cord blood.
  • Echocardiographic assessment of cardiac functions.

Main Results:

  • Infants of preeclamptic mothers showed significantly higher TAC, TOS, and OSI levels in cord blood compared to controls.
  • No significant correlation was found between echocardiographic measurements and TAC, TOS, or OSI levels.

Conclusions:

  • The oxidant-antioxidant balance is disturbed in infants born to preeclamptic mothers, favoring oxidants.
  • Echocardiographic parameters in neonates appear unaffected by the observed alterations in oxidant status.
Abstract

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