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A Hydrolyzed Chicken Extract CMI-168 Enhances Learning and Memory in Middle-Aged Mice.

Sheng-Feng Tsai1,2, Chia-Yuan Chang3, Shan-May Yong4

  • 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. eric04142000@hotmail.com.

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Chicken Meat Ingredient-168 (CMI-168) improved non-spatial memory in middle-aged mice without altering hippocampal neuroplasticity. This dietary supplement also enhanced stress resilience, suggesting novel cognitive and stress-management benefits.

Keywords:
anti-stressessence of chickenhippocampusneuroadaptationneuroplasticity

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Cognitive Science

Background:

  • Dietary supplements and nutrients can impact cognitive processes and emotions.
  • Chicken Meat Ingredient-168 (CMI-168) has shown prior cognitive enhancement in humans, but its mechanisms are unknown.
  • Investigating CMI-168's effects on hippocampal neuroplasticity and memory is crucial for understanding its benefits.

Purpose of the Study:

  • To investigate the effects of CMI-168 on hippocampal neuroplasticity and memory in middle-aged mice.
  • To determine if CMI-168 influences non-spatial and spatial memory functions.
  • To explore the impact of CMI-168 on stress resilience.

Main Methods:

  • Middle-aged mice were divided into a CMI-168 group (150 mg/kg/day) and a control Chow group for 6 weeks.
  • Cognitive function was assessed using the novel object recognition test and Morris Water Maze.
  • Hippocampal neuroplasticity markers, including long-term potentiation and dendritic complexity, were evaluated.

Main Results:

  • CMI-168 supplementation did not affect body weight, food intake, or exploratory behavior.
  • The CMI-168 group demonstrated improved non-spatial memory but not spatial memory compared to controls.
  • No significant differences were observed in hippocampal neuroplasticity markers between groups.
  • CMI-168 appeared to protect mice against stress-induced weight loss.

Conclusions:

  • Dietary CMI-168 supplementation enhances learning and memory in middle-aged mice, independent of hippocampal structural or functional changes.
  • CMI-168 confers resilience to stress, a finding that warrants further investigation.
  • The study suggests CMI-168 may offer benefits for cognitive function and stress management.