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Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance

Siwen Yang1, Yuhan Meng2, Jingmin Yan3

  • 1School of Life Sciences, Northeast Normal University, 130024 Jilin, China. yangsw776@nenu.edu.cn.

Molecules (Basel, Switzerland)
|December 26, 2018
PubMed

Insights

The edible fungus Armillariella mellea extract (AAMP) shows promise for treating type 2 diabetes. This polysaccharide-rich compound effectively lowers blood glucose and improves insulin resistance by regulating lipid metabolism.

Area of Science:

  • Mycology
  • Biochemistry
  • Pharmacology

Background:

  • The edible fungus *Amillariella mellea* exhibits various biological activities, but its anti-diabetic effects remain largely unexplored.
  • Polysaccharides are considered the primary bioactive components responsible for such activities.
  • Extraction methods are crucial for isolating these polysaccharides for therapeutic evaluation.

Purpose of the Study:

  • To investigate the hypoglycemic effects of an alkali-extracted polysaccharide-enriched fraction from *Amillariella mellea* (AAMP).
  • To elucidate the underlying mechanisms of AAMP's action in a rat model of type 2 diabetes.

Main Methods:

  • Extraction of polysaccharide-enriched fraction (AAMP) from *Amillariella mellea* fruiting bodies using NaOH.
  • Induction of type 2 diabetes in rats via high-fat diet (HFD) and dexamethasone (DEX) co-treatment.
  • Oral administration of AAMP to diabetic rats and assessment of glycemic control, insulin resistance, and lipid metabolism markers.

Main Results:

  • A high dose of AAMP significantly reduced fasting blood glucose levels.
  • AAMP administration improved glucose tolerance and insulin resistance in HFD/DEX-induced diabetic rats.
  • AAMP modulated lipid metabolism by enhancing LPL, ATGL, and HSL expression, decreasing serum triglycerides, and suppressing SREBP-1c expression, thereby inhibiting hepatic lipid accumulation.

Conclusions:

  • The hypoglycemic and insulin-sensitizing effects of AAMP are linked to its regulation of lipid metabolism.
  • AAMP demonstrates potential as a novel natural therapeutic agent or health food for diabetes management.
Keywords:
Amillariella melleainsulin resistancelipid metabolismpolysaccharide

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