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Protein Engineering by Yeast Surface Display
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Tackling Cancer with Yeast-Based Technologies.

Raphael Ferreira1, Angelo Limeta2, Jens Nielsen3

  • 1Department of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.

Trends in Biotechnology
|December 26, 2018
PubMed
Summary
This summary is machine-generated.

Researchers are using genetically engineered yeast, which shares similarities with tumor cells, to advance cancer research. This review highlights yeast

Keywords:
CRISPRSGAcancer vaccineshumanized antibodyimmunotherapymetabolic engineering

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Area of Science:

  • Biochemistry
  • Genetics
  • Oncology

Background:

  • Yeast (Saccharomyces cerevisiae) possesses genetic and metabolic pathways analogous to human tumor cells.
  • Precise genetic engineering techniques are well-established in yeast, facilitating its use as a model system.

Purpose of the Study:

  • To review the advancements in utilizing yeast as a model organism in cancer research.
  • To explore the application of yeast in understanding cancer biology and developing novel cancer therapies.

Main Methods:

  • Literature review of studies employing yeast in cancer research.
  • Analysis of yeast's role in investigating tumorigenic mechanisms.
  • Examination of yeast-based platforms for drug discovery and development.

Main Results:

  • Yeast models have been instrumental in elucidating cancer biology and tumorigenesis.
  • Yeast facilitates the development of high-throughput screening platforms for anticancer drug discovery.
  • Industrial-scale production of anticancer drugs and development of novel immunotherapies are enabled by yeast technology.

Conclusions:

  • Yeast serves as a powerful and versatile model organism for cancer research.
  • Leveraging yeast advances preclinical cancer studies and therapeutic development, from drug discovery to immunotherapy.