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Related Experiment Video

Updated: Jan 31, 2026

Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks

Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks

Published on: December 5, 2014

Selective sensory deafferentation induces structural and functional brain plasticity.

Raphael F Casseb¹, Brunno M de Campos², Alberto R M Martinez²

¹Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, SP 13083-888, Brazil; Neurophysics Group, Gleb Wataghin Physics Institute, University of Campinas, Campinas, SP 13083-859, Brazil.

Neuroimage. Clinical

|December 26, 2018

Summary

Sensory neuronopathy (SN) causes widespread sensory loss, impacting brain organization. Brain imaging reveals caudate nucleus hypertrophy and altered white matter microstructure, highlighting brain plasticity and informing neurorehabilitation.

Keywords:

Deafferentation MRI Plasticity Sensory neuronopathy Sensory-motor integration

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Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks

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Area of Science:

Neuroscience
Neuroimaging
Neurology

Background:

Sensory-motor integration models explain how sensory input guides movement.
Sensory neuronopathy (SN) involves severe sensory loss, offering a unique model to study deafferentation's effects on the brain.

Purpose of the Study:

To investigate the impact of sensory deafferentation in SN patients on brain structure and function using MRI.
To explore how the brain reorganizes in response to profound sensory loss.

Main Methods:

Structural MRI to assess gray matter (GM) volume.
Diffusion MRI to analyze white matter (WM) microstructure in regions of interest (ROIs).
Functional MRI during a finger-tapping task to evaluate brain activation.

Main Results:

Hypertrophy of the caudate nucleus was observed in SN patients.
Reduced fractional anisotropy (FA) in WM ROIs around the thalamus and striatum.
Altered finger-tapping-related activation in posterior parietal cortex and cerebellar medial areas, particularly in patients with long disease duration.

Conclusions:

Findings emphasize the caudate nucleus's role in sensory-motor integration and suggest an inhibitory function for a thalamus-striatum tract.
Results confirm adult brain plasticity and provide insights for developing neurorehabilitation strategies for sensory loss disorders.