Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Base Excision Repair01:54

Base Excision Repair

26.3K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.3K
Base Excision Repair01:54

Base Excision Repair

5.1K
5.1K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington's disease animal model" [Pharmacol. Res. 219 (2025) 107905].

Pharmacological research·2026
Same author

The Need for Staging System in Colony Stimulating Factor 1 Receptor-Related Disorder.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Advances and unmet needs in fluid and tissue biomarkers in Parkinson's disease.

Neural regeneration research·2026
Same author

Charting the translational pathway: ISSCR best practices for the development of PSC-derived therapies.

Stem cell reports·2026
Same author

A distinct lineage pathway drives parvalbumin chandelier cell fate in human interneuron reprogramming.

Science advances·2026
Same author

STEM-PD trial protocol: a multi-centre, single-arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell-derived dopaminergic cells for Parkinson's disease.

BMJ open·2025
Same journal

The road towards faster development of novel pharmacotherapies for persons with Parkinson's disease.

Journal of Parkinson's disease·2026
Same journal

Mortality rate, main causes of death and factors associated with higher mortality hazard in late stage Parkinson's disease.

Journal of Parkinson's disease·2026
Same journal

Abnormal motor control effort costs in Parkinson's disease patients with apathy.

Journal of Parkinson's disease·2026
Same journal

Deficits in episodic memory and executive functions in relation to CB1 receptor availability in Parkinson's disease.

Journal of Parkinson's disease·2026
Same journal

Rationale and current status of fecal microbiota transplantations for Parkinson's disease.

Journal of Parkinson's disease·2026
Same journal

Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review.

Journal of Parkinson's disease·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
10:30

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Published on: May 23, 2014

11.1K

Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies.

Claire Henchcliffe1, Malin Parmar2

  • 1Department of Neurology, Weill Cornell Medical College, and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York NY, USA.

Journal of Parkinson'S Disease
|December 26, 2018
PubMed
Summary
This summary is machine-generated.

Stem cell technology offers new hope for Parkinson's disease cell replacement therapy, potentially overcoming limitations of fetal tissue transplants for more effective and safer dopamine neuron restoration.

Keywords:
Dopamine neuronsParkinson’s diseasestem cell therapy

More Related Videos

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

8.8K
Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
09:36

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Published on: August 29, 2018

10.8K

Related Experiment Videos

Last Updated: Jan 31, 2026

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
10:30

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Published on: May 23, 2014

11.1K
Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

8.8K
Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
09:36

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Published on: August 29, 2018

10.8K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Cell replacement therapy aims to restore dopaminergic function in Parkinson's disease (PD).
  • Fetal tissue transplants demonstrated feasibility but had drawbacks like graft-induced dyskinesia.
  • Limitations of fetal cell transplantation necessitate alternative approaches.

Purpose of the Study:

  • To explore the potential of stem cell-based therapies for Parkinson's disease cell replacement.
  • To discuss how advancements in stem cell technology can overcome challenges associated with fetal tissue.
  • To project the future impact of stem cell therapies on Parkinson's disease treatment over the next two decades.

Main Methods:

  • Review of current cell replacement strategies for Parkinson's disease.
  • Analysis of stem cell technology advancements, including generation of dopaminergic neurons.
  • Discussion on various stem cell sources: embryonic stem cells, induced pluripotent stem cells, and patient-derived cells.

Main Results:

  • Stem cell technology enables the generation of specific cell types, like dopaminergic neurons, with controlled quality and safety.
  • Stem cell-derived neurons are predicted to offer robust outcomes and avoid graft-induced dyskinesia seen with fetal grafts.
  • Expanded starting material options (hESCs, iPSCs, autologous cells) enhance therapeutic development.

Conclusions:

  • Stem cell-based therapies hold significant promise for advancing Parkinson's disease cell replacement.
  • Future treatments may offer improved efficacy and safety compared to historical fetal cell transplantation methods.
  • Continued advancements in stem cell technology and knowledge will likely revolutionize Parkinson's disease therapeutics.