Rhabdomyolysis and Acute Poisoning; a Brief Report.

Area of Science:

• Toxicology
• Clinical Chemistry

Background:

• Emerging evidence suggests serum creatinine phosphokinase (CPK) may predict outcomes in poisoned patients.
• This study evaluated the association between initial serum CPK levels and patient outcomes.

Purpose of the Study:

• To assess the correlation of early serum CPK levels with clinical outcomes in poisoned patients.
• To identify CPK as a potential biomarker for predicting severe outcomes like ICU admission and acute kidney injury (AKI).

Main Methods:

• Retrospective cross-sectional study of 318 poisoned patients (ages 13-70).
• Data collected from a major medical toxicology center over six years.
• Analyzed serum CPK levels within the first 24 hours of presentation.

Main Results:

• No significant correlation found between serum CPK and poisoning cause, age, sex, seizure, consciousness level, or hospital stay duration.
• Significantly higher serum CPK levels were observed in patients admitted to the ICU, with AKI, hyperkalemia, hypophosphatemia, and hypocalcemia.
• A CPK cutoff of 10000 IU/L demonstrated 83.8% sensitivity and 68.8% specificity for predicting AKI.

Conclusions:

• Serum CPK shows potential as a screening tool for identifying poisoned patients requiring ICU admission.
• Elevated CPK levels may indicate a higher risk of developing acute kidney injury (AKI).
• Further research can validate CPK's role in managing poisoned patients.