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Updated: Jan 31, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
Antifungal activity study of the monoterpene thymol against Cryptococcus neoformans
Anna Paula de Castro Teixeira1, Rafaela de Oliveira Nóbrega1, Edeltrudes de Oliveira Lima2
1Departament of Pharmacy of Health Academic Unit, Federal University of Campina Grande, Cuité, Brazil.
Abstract:
Cryptococcus neoformans is a yeast fungus, which causes cryptococcosis, triggered by basidiospore inhalation and consequent dissemination to the central nervous system. In this study, we analyzed the antifungal action of thymol against 10 clinical strains of C. neoformans and analyzed the interaction of this monoterpene with sterols. The MICs of thymol ranged from 20 to 51 μg/ml, while the MFC values varied between 40 and 101 μg/ml. For the strains ICB-2601 and LM-39, in the presence of ergosterol, the MIC of thymol was 64 μg/ml, and in the presence of cholesterol, its MIC was 32 μg/ml. Based on the results, thymol presents antifungal action and seems to interact with ergosterol, but not with cholesterol. Complementary studies are needed to analyze its full effects.
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