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Updated: Jan 31, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Mental rotation task in bipolar disorder.
Adrian Andrzej Chrobak1, Szymon Jeziorko2, Anna Tereszko1
1Klinika Psychiatrii Dorosłych, Uniwersytet Jagielloński, Collegium Medicum.
Euthymic patients with bipolar disorder (BD) exhibit significant visuospatial deficits, demonstrated by slower reaction times and lower accuracy on the Mental Rotation Task. These findings highlight cognitive impairments even during stable periods of the illness.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Bipolar disorder (BD) is known to impact cognitive and motor functions.
- Existing research indicates visuospatial processing and memory deficits in BD patients.
- The Mental Rotation Task (MRT) has not been previously utilized to assess these specific deficits.
Purpose of the Study:
- To introduce the Mental Rotation Task (MRT) as a method for evaluating visuospatial deficits.
- To assess visuospatial processing and memory impairments in euthymic patients with bipolar disorder.
Main Methods:
- Recruited 31 euthymic BD patients and 27 healthy controls matched for age and education.
- Administered a digital version of the Mental Rotation Task (MRT).
- Participants compared rotated figures to identify similarities or differences.
Main Results:
- BD patients showed significantly longer reaction times across various rotation angles (-90, -45, 45, 90 degrees, and 0 degrees).
- Accuracy rates were significantly lower in the BD group compared to controls for the overall test and specific conditions.
- No significant differences in performance were observed at rotation angles of -135, 135, or 180 degrees.
Conclusions:
- The findings confirm visuospatial deficits in bipolar disorder, consistent with prior research.
- This study demonstrates, for the first time, the presence of mental rotation deficits in euthymic BD patients.
- The Mental Rotation Task is a viable tool for identifying visuospatial impairments in BD during stable phases.
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