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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
[Actuality of pathomorphogenesis investment in calcific aortic valve stenosis.]
N I Gulyaev1, A S Galenko1, K L Kozlov1,2
1S.M.Kirov Military Medical Academy, 6, Acad. Lebedeva str., St. Petersburg, 194044, Russian Federation;
Insights
Degenerative aortic stenosis is the most common age-related heart valve disease in industrial countries. Insufficient diagnosis limits necessary aortic valve surgeries, highlighting the need for better epidemiological data.
Area of Science:
- Cardiology
- Gerontology
- Public Health
Background:
- Aging populations in industrial nations experience a rise in age-related diseases.
- Sclerodegenerative heart valve diseases show a dramatic increase, impacting public health.
- Acquired heart valve diseases represent a significant health concern in aging demographics.
Purpose of the Study:
- To investigate the epidemiology of sclerodegenerative heart valve diseases.
- To identify the most prevalent type of acquired heart valve disease.
- To highlight the diagnostic and treatment gaps in managing aortic valve disease.
Main Methods:
- Echocardiography was used to examine 814 patients of various ages and genders.
- Data collection focused on patients with acquired heart valve diseases.
- Epidemiological analysis of heart valve disease prevalence was performed.
Main Results:
- Degenerative aortic stenosis was identified as the most common heart valve disease in the observed cohort.
- Less than 20% of required aortic valve replacement surgeries are performed in Russia.
- Inadequate and delayed diagnosis is the primary barrier to timely surgical intervention.
Conclusions:
- Degenerative aortic stenosis is a critical issue in aging populations.
- There is a significant disparity between the need for and provision of aortic valve surgery.
- Further research into the epidemiology and underlying causes of sclerodegenerative heart valve diseases is essential.
Abstract:
The increasing of lifetime industrial countries population leads to widespreading diseases of age. Dramatic growth of sclerodegenerative heart valve diseases in last decades is one of the best examples. We observed 814 patients of different gender and age with acquired heart valve diseases using echocardiography. We found out that the most common heart valve disease is degenerative aortic stenosis. Unfortunately, nowadays in Russia no more than 20% of the necessary operations on aortic valve are performed, the main reason of it is, more likely, insufficient and untimely diagnosis of the defect. However, the surgery of vice serves only as a mechanical elimination of the problem, without affecting the causes which led to its development. So we need modern data about sclerodegenerative heart valve diseases epidemiology and discloses actuality of the problem.
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