Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Editing02:23

RNA Editing

9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K
Role of Septins01:02

Role of Septins

2.2K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

417
Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
417
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

1.9K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
1.9K
Role-Based Identity01:21

Role-Based Identity

204
Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
204
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer: biomarker analyses from a prospective phase II trial.

BMC medicine·2025
Same author

Quantitative and Dynamic ctDNA as a Biomarker of Response and Survival in Patients With Advanced Lung Squamous Cell Carcinoma Receiving Immunochemotherapy or Chemotherapy Alone.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2025
Same author

Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma.

Molecular cancer·2025
Same author

Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study.

JMIR research protocols·2023
Same author

Validation of the prognostic value of a three-gene signature and clinical parameters-based risk score in prostate cancer patients.

The Prostate·2023
Same author

A Novel Risk Score (P-score) Based on a Three-Gene Signature, for Estimating the Risk of Prostate Cancer-Specific Mortality.

Research and reports in urology·2022

Related Experiment Video

Updated: Jan 31, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K

ADAR1 Editing and its Role in Cancer.

Li-Di Xu1, Marie Öhman2

  • 1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, 106 91 Stockholm, Sweden. lidi.xu@su.se.

Genes
|December 27, 2018
PubMed
Summary
This summary is machine-generated.

Aberrant RNA editing by adenosine deaminases acting on RNA (ADARs), particularly ADAR1, drives cancer progression and immune evasion. Dysregulation of ADAR1 promotes tumorigenesis by altering gene expression and suppressing innate immunity.

Keywords:
ADAR1RNA editingadenosine deaminationcancerinnate immunity

More Related Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.6K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.1K

Related Experiment Videos

Last Updated: Jan 31, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.6K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.1K

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • Somatic mutations and immune escape are key factors in cancer.
  • RNA mutations, including adenosine to inosine (A-to-I) editing, significantly influence tumor development and immune evasion.
  • A-to-I editing, catalyzed by adenosine deaminases acting on RNA (ADARs), creates transcriptome diversity and can lead to non-synonymous codon changes, alternative splicing, and microRNA dysregulation.

Purpose of the Study:

  • To review the regulatory mechanisms of ADAR1 during tumorigenesis.
  • To discuss how aberrant RNA editing by ADAR1 contributes to cancer progression.
  • To hypothesize the role of elevated ADAR1 in suppressing innate immunity in cancer cells.

Main Methods:

  • Review of existing literature on ADAR1, RNA editing, and cancer.
  • Analysis of transcriptomic data and sequencing studies.
  • Discussion of regulatory pathways involving ADAR1 and type I interferon.

Main Results:

  • ADAR1 is frequently overexpressed in various cancers (breast, lung, liver, esophageal, leukemia).
  • ADAR1 dysregulation leads to aberrant editing of specific substrates, promoting cancer progression.
  • ADAR1 regulates type I interferon signaling, a known barrier to tumor formation.

Conclusions:

  • Elevated ADAR1 levels contribute to cancer development and progression through aberrant RNA editing.
  • ADAR1 plays a critical role in suppressing innate immune responses within cancer cells.
  • Understanding ADAR1's role is crucial for developing novel cancer therapies targeting RNA editing and immunity.