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Published on: October 6, 2011
Triterpenoids with α-glucosidase inhibitory activity from Artemisia argyi
Lai-Bin Zhang1, Jia-Jing Chang1, Li-Min Guo1
1School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Abstract:
Two new nordammarane-type triterpenoids, 3β-acetoxy-20-oxo-21-nordammaran-23-carboxylic acid methyl ester (1) and 3β-acetoxy-17β-dammaranic acid (2), along with two known cycloartane-type triterpenoids (3-4), were isolated from the petroleum ether-soluble extract of Artemisia argyi. Their structures were elucidated based on 1D and 2D NMR spectroscopic data analysis. All compounds were evaluated for their α-glucosidase inhibitory activity in vitro. Compounds 1-4 exhibited significant inhibitory effects on α-glucosidase with IC50 values ranging from 38.34 ± 0.23 to 105.54 ± 0.33 μM.
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