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Updated: Jan 31, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model
Diya Wang1,2, Shanshan Xu1, Kejia Zhang3
1Department of Biomedical Engineering, School of Life Science and Technology, Xi' an Jiaotong University, Xi' an, 710049, China.
Purpose:
This study aimed to develop a fast scheme of multiparametric perfusion functional imaging (PFI) based on dynamic contrast-enhanced ultrasound (DCEUS) for assessing renal microvascular hemodynamics.
Method:
The flow process in the DCEUS-based PFI was modified step-by-step to improve its operational efficiency, which was validated through in vivo renal perfusion experiments. A multiparametric model with a comprehensive coefficient of imaging quality (CIQ) was then built on four terms of the average information entropy, contrast, gray, and noise coefficient of PFIs to evaluate the sacrifice of imaging quality during modifications of DCEUS-based PFI.
Results:
The multiparametric model successfully evaluated modifications of DCEUS-based PFI from multiple perspectives (R2 = 0.73, P < 0.01). Compared with the raw scheme in the renal sagittal and coronal planes, the fast PFI scheme significantly improved its operational efficiency by 62.82 ± 1.07% (P < 0.01) and the nine PFIs simultaneously maintained a similar CIQ of 0.26 ± 0.06.
Conclusions:
The inhomogeneous hemodynamic distributions with a ring-like feature in the renal microvasculature were accurately and efficiently characterized by the fast PFI scheme. The fast PFI scheme can be applied for early diagnosis, follow-up evaluation and monitoring treatment of chronic kidney disease.
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