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Skin Cancer Prevention: A Review of Current Oral Options Complementary to Sunscreens
Abstract:
The incidence of non-melanoma skin cancer (NMSC) is dramatically increasing worldwide, despite the increased use of improved sunscreens. In 2014, the Surgeon General estimated that 2.2 to 5.0 million people are treated annually for NMSC.1-3 For decades, recommendations for sun protection have remained insufficient; subsequently, the numbers of newly diagnosed skin cancers continue to rise, and there is a need for additional preventative measures beyond sunscreens. The objective of this article is to review current oral prescription medications as well as supplements that may play an important role in skin cancer prevention. J Drugs Dermatol. 2018;17(12):1266-1271.
Insights
Non-melanoma skin cancer (NMSC) is rising despite sunscreen use. This review explores oral medications and supplements as potential preventative measures against NMSC.
Area of Science:
- Dermatology
- Oncology
- Preventative Medicine
Background:
- The global incidence of non-melanoma skin cancer (NMSC) is increasing.
- Current sun protection recommendations, including sunscreen use, are insufficient to curb rising NMSC rates.
- There is a critical need for additional preventative strategies beyond topical sunscreens.
Purpose of the Study:
- To review existing oral prescription medications for NMSC prevention.
- To identify supplements that may contribute to skin cancer prevention.
- To provide an overview of novel approaches to NMSC prevention.
Main Methods:
- Literature review of peer-reviewed studies.
- Analysis of clinical trials and epidemiological data.
- Synthesis of information on oral agents and supplements for skin cancer prevention.
Main Results:
- Certain oral prescription medications show promise in NMSC prevention.
- Specific dietary supplements may offer protective benefits against skin cancer.
- Evidence suggests a role for systemic approaches in NMSC prevention.
Conclusions:
- Oral medications and supplements represent a potential adjunct to traditional sun protection methods.
- Further research is warranted to establish the efficacy and safety of these agents.
- Systemic prevention strategies could significantly impact the rising NMSC epidemic.
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