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Related Experiment Video

Updated: Jan 31, 2026

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
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Ag/CdO NP-Engineered Magnetic Electrochemical Aptasensor for Prostatic Specific Antigen Detection.

Yuan Zhao1, Linyan Cui1, Yali Sun1

  • 1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi , Jiangsu 214122 , China.

ACS Applied Materials & Interfaces
|December 27, 2018
PubMed
Summary
This summary is machine-generated.

A novel magnetic electrochemical aptasensor detects prostate-specific antigen (PSA) using Ag/CdO nanoparticles. This sensitive biosensor offers accurate PSA detection for potential tumor biomarker applications.

Keywords:
Ag/CdO NPsAptamersDetectionGO/Fe3O4 NSsPSA

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Area of Science:

  • Electrochemistry
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Prostate-specific antigen (PSA) is a key biomarker for prostate cancer detection.
  • Development of sensitive and specific biosensors is crucial for early cancer diagnosis.
  • Electrochemical aptasensors offer advantages in sensitivity, specificity, and cost-effectiveness.

Purpose of the Study:

  • To establish a simple magnetic electrochemical aptasensor for sensitive PSA detection.
  • To engineer Ag/CdO nanoparticles and Fe3O4/graphene oxide nanosheets for enhanced sensing performance.
  • To evaluate the aptasensor's sensitivity, accuracy, and potential for tumor biomarker detection.

Main Methods:

  • Fabrication of Ag/CdO nanoparticles with strong electroreduction properties.
  • Assembly of aptamer-modified Ag/CdO NPs onto superparamagnetic Fe3O4/graphene oxide nanosheets.
  • Utilizing a magnetic electrode for PSA detection based on aptamer-PSA interaction and signal changes.

Main Results:

  • The aptasensor demonstrated superior electroactive properties and efficient electron transfer.
  • Sensitive and accurate detection of PSA in the range of 50 pg/mL to 50 ng/mL was achieved.
  • A low limit of detection (LOD) of 28 pg/mL was obtained, indicating high sensitivity.

Conclusions:

  • The developed magnetic electrochemical aptasensor provides a reliable platform for PSA detection.
  • The protocol shows potential for extension to detect various tumor biomarkers with high sensitivity and specificity.
  • This approach offers a promising tool for early cancer diagnosis and monitoring.