Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonionic contrast agents and coagulation.

P Dawson1

  • 1Royal Postgraduate Medical School, London, England.

Investigative Radiology
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Second-generation nonionic contrast media exhibit the lowest chemotoxicity due to their chemical structure. While they cause minor red blood cell aggregation, clot formation is rare and linked to syringe material, not the contrast agent itself.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining spatial variation for immunisation coverage in pregnant women: A nationwide and geospatial retrospective cohort study in Aotearoa New Zealand.

Social science & medicine (1982)·2023
Same author

Publisher Correction: Impact of alloy fluctuations and Coulomb effects on the electronic and optical properties of c-plane GaN/AlGaN quantum wells.

Scientific reports·2020
Same author

Impact of alloy fluctuations and Coulomb effects on the electronic and optical properties of c-plane GaN/AlGaN quantum wells.

Scientific reports·2019
Same author

The Ostom-i™ Alert Sensor: a new device to measure stoma output.

Techniques in coloproctology·2018
Same author

Resonant photoluminescence studies of carrier localisation in c-plane InGaN/GaN quantum well structures.

Journal of physics. Condensed matter : an Institute of Physics journal·2018
Same author

Origin of enhancement in Raman scattering from Ag-dressed carbon-nanotube antennas: experiment and modelling.

Physical chemistry chemical physics : PCCP·2018
Same journal

3D Freehand Ultrasound Imaging of Optic Nerve Sheath.

Investigative radiology·2026
Same journal

Iodinated Contrast Media Hypersensitivity in 115,966 Patients: Risk Factors, Severity Profiles, and the Impact of Iodine Concentration on Reaction Risk.

Investigative radiology·2026
Same journal

Improvement of Lung Nodule Volumetric Accuracy with Photon-counting Computed Tomography Over Energy-integrating Computed Tomography in Low-dose Screening: A Phantom Study.

Investigative radiology·2026
Same journal

Photon-counting CT in Anterior Cervical Discectomy and Fusion: Improved Metal Artifact Reduction and Impact on Bone Fusion Assessment.

Investigative radiology·2026
Same journal

Quantitative Synthetic MRI in Body Imaging: Technical Basis, Current Applications, and Future Directions.

Investigative radiology·2026
Same journal

Nonclinical Safety Assessment of Digadoglucitol, a Novel Magnetic Resonance Imaging Contrast Agent for the Central Nervous System.

Investigative radiology·2026
See all related articles

Area of Science:

  • Radiology and Imaging
  • Biomedical Engineering
  • Toxicology

Background:

  • Contrast media are essential in medical imaging.
  • Chemotoxicity and hematologic effects of contrast media vary based on their chemical properties.
  • Second-generation nonionic contrast media are designed for reduced toxicity.

Purpose of the Study:

  • To evaluate the chemotoxicity of second-generation nonionic contrast media compared to conventional ionic agents.
  • To assess the hematologic effects, specifically red blood cell aggregation and coagulation, of different contrast media.
  • To determine the influence of chemical structure on the safety profile of contrast agents.

Main Methods:

  • Comparative analysis of chemical structures of nonionic and ionic contrast media.

Related Experiment Videos

  • Microscopic observation of red blood cell aggregation with nonionic (iohexol) and ionic (diatrizoate) agents.
  • Coagulation experiments using different syringe materials (plastic, glass) with iohexol and diatrizoate.
  • ELISA assay for fibrinopeptide A to assess coagulation activation.

    • Main Results:

    • Second-generation nonionic agents demonstrate the lowest chemotoxicity due to hydrophilic group distribution masking hydrophobic iodine atoms.
    • Red blood cell aggregation was observed with both agent types but was easily reversible with nonionic media.
    • Clot formation was infrequent and primarily associated with the syringe material, not the contrast agent (iohexol or diatrizoate).

    Conclusions:

    • Second-generation nonionic contrast media possess a favorable low toxicity profile.
    • The observed hematologic effects of nonionic agents are clinically insignificant.
    • Syringe material plays a significant role in potential blood clot formation when using contrast media.