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Updated: Jan 31, 2026

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent
Published on: November 30, 2017
Differential recordings of local field potential: A genuine tool to quantify functional connectivity
Gabriel Meyer1, Julien Carponcy1, Paul Antoine Salin2
1Forgetting and Cortical Dynamics Team, Lyon Neuroscience Research Center (CRNL), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), University Lyon 1, Lyon, France.
Abstract:
Local field potential (LFP) recording is a very useful electrophysiological method to study brain processes. However, this method is criticized for recording low frequency activity in a large area of extracellular space potentially contaminated by distal activity. Here, we theoretically and experimentally compare ground-referenced (RR) with differential recordings (DR). We analyze electrical activity in the rat cortex with these two methods. Compared with RR, DR reveals the importance of local phasic oscillatory activities and their coherence between cortical areas. Finally, we show that DR provides a more faithful assessment of functional connectivity caused by an increase in the signal to noise ratio, and of the delay in the propagation of information between two cortical structures.
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