Chitosan/beidellite nanocomposite as diclofenac carrier

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Chitosan (CS) and sodium beidellite (Na-Bd) are biocompatible materials with potential in drug delivery.
• Anionic pharmaceutical ingredients require effective carriers for modified release.
• Diclofenac sodium (DS) is a widely used anionic non-steroidal anti-inflammatory drug.

Purpose of the Study:

• To synthesize and characterize a novel clay/polymer hybrid nanocomposite using chitosan and sodium beidellite.
• To investigate the loading capacity and encapsulation efficiency of diclofenac sodium within the nanocomposite.
• To evaluate the drug release profile of diclofenac sodium from the developed hybrid material.

Main Methods:

• Synthesis of chitosan/sodium beidellite nanocomposite.
• Loading of diclofenac sodium using the intercalation solution technique.
• Solid-state characterization using X-ray diffraction, FTIR, thermal analysis, and HRTEM-EDX.
• Quantification of drug loading and encapsulation efficiency via UV-Vis spectroscopy.
• In vitro drug release studies in simulated intestinal fluid.

Main Results:

• Successful synthesis of chitosan/sodium beidellite nanocomposite hybrids.
• Confirmation of chemical and physical interactions between diclofenac sodium and the nanocomposite.
• Achieved high drug loading capacity and encapsulation efficiency for diclofenac sodium.
• Demonstrated a modified cumulative release profile of diclofenac sodium in simulated intestinal fluid.

Conclusions:

• The developed chitosan/sodium beidellite clay/polymer hybrids are effective carriers for anionic drugs.
• These nanocomposites show significant potential for designing modified-release dosage forms.
• This research contributes to the advancement of nanocarrier systems for pharmaceutical applications.