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Evolution of Biomarkers of Atherogenic Risk in Liver Transplantation Recipients

L M C Linhares1, C P Oliveira1, M R Alvares-da-Silva2

  • 1Department of Gastroenterology (LIM-07/LIM-37), University of São Paulo School of Medicine, São Paulo, Brazil.

Transplantation Proceedings
|December 28, 2018
PubMed

Insights

Cardiovascular disease is a major risk after liver transplantation. Atherogenic risk biomarkers significantly increased in liver transplant recipients (LTRs) within 48 months, preceding coronary plaque development.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Biomarker Research

Background:

  • Cardiovascular disease (CVD) is a primary cause of mortality post-liver transplantation (LT).
  • Understanding atherogenic risk evolution in liver transplant recipients (LTRs) is crucial for long-term outcomes.

Purpose of the Study:

  • To evaluate the progression of atherogenic risk in LTRs.
  • To assess changes in biomarkers of endothelial dysfunction, inflammation, and oxidative stress.
  • To correlate these biomarkers with cardiac imaging findings.

Main Methods:

  • Prospective study of 36 LTRs, followed for 48 months post-LT.
  • Measurement of serum biomarkers: sICAM-1, sVCAM-1, serum amyloid A, and myeloperoxidase at 12 and 48 months.
  • Cardiac computed tomography (CT) and coronary artery calcium score (CACS) performed at 12 months.

Main Results:

  • Significant increases in sVCAM-1, sICAM-1, myeloperoxidase, and serum amyloid A were observed from 12 to 48 months post-LT (P < .001).
  • Prevalence of metabolic syndrome risk factors increased during the study.
  • Cardiac CT showed mild (19%) and moderate (25%) coronary artery disease.

Conclusions:

  • Serum biomarkers indicating atherogenic risk significantly increase in LTRs.
  • These biomarker elevations occur before the development of coronary plaques.
  • No direct association was found between these biomarkers and metabolic syndrome or coronary artery calcium scores.
Abstract

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