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Updated: Jan 31, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Redox and pH responsive polymeric vesicles constructed from a water-soluble pillar[5]arene and a paraquat-containing
Jiaxing Zhong1,2, Qiuju Tang1,2, Yanshan Ju1,2
1a Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT) , Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University , Hangzhou , China.
Abstract:
Herein, for rate-tunable controlled release, pH and redox dual responsive polymeric vesicles were constructed based on host-guest interaction between a water soluble pillar[5]arene (WP5) and a paraquat-containing block copolymer (BCP) in water. The yielding polymeric vesicles can be further applied in the controlled release of a hydrophilic model drug, doxorubicin hydrochloride (DOX). The drug release rate is regulated depending on the type of single stimulus or the combination of two stimuli. Meanwhile, DOX-loaded polymeric vesicles present anticancer activity in vitro comparable to free DOX under the studied conditions, which may be important for applications in the therapy of cancers as a controlled-release drug carrier.
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