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SOX 2 Expression in Human Pituitary Adenomas-Correlations With Pituitary Function.

Cristina Capatina1,2, Anca Maria Cimpean3,4, Marius Raica5,4

  • 1Endocrinology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

In Vivo (Athens, Greece)
|December 28, 2018
PubMed
Summary

SOX2 expression varies in pituitary adenomas, impacting tumor function. Higher SOX2 levels were linked to secreting adenomas and hormone deficiencies in non-functioning tumors.

Keywords:
SOX2non-functional pituitary adenomapituitary adenomassecreting adenoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Pituitary adenomas are common tumors.
  • Understanding their molecular basis is crucial for treatment.

Purpose of the Study:

  • To investigate SOX2 expression in pituitary adenomas.
  • To correlate SOX2 levels with tumor secretory status and clinical features.

Main Methods:

  • Histopathology and immunohistochemistry were used.
  • SOX2 and pituitary hormone co-expression was analyzed.
  • 34 pituitary adenoma cases were studied.

Main Results:

  • SOX2 expression was found in 47.05% of pituitary adenomas.
  • SOX2 positivity was significantly higher in hormone-secreting adenomas (p=0.041).
  • SOX2-negative tumors correlated with corticotrophin (p=0.047) and gonadotrophin (p=0.041) deficiency.

Conclusions:

  • SOX2 exhibits differential expression in pituitary adenomas.
  • SOX2 influences the secretory state and clinical behavior of these tumors.