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Updated: Jan 31, 2026
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Phase II Study of Weekly Amrubicin for Refractory or Relapsed Non-small Cell Lung Cancer
Chiyoe Kitagawa1,2, Masahiro Iwasaku3, Yoshihito Kogure4
1Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan kitagawc@nnh.hosp.go.jp.
Background:
Amrubicin is usually administered on days 1-3 every 3 weeks by intravenous infusion. However, it causes severe hematological toxicity, especially febrile neutropenia. It was reported that weekly administration confers higher dose intensity, less severe adverse events, and anti-tumor activity that is as effective as that of treatment with a conventional schedule.
Patients And Methods:
Weekly amrubicin was administered at a dose of 60 mg/m2 on days 1 and 8 every 3 weeks. The primary endpoint was overall response rate.
Results:
A total of 33 patients were enrolled. The overall response rate was 6.1% (95% confidence interval(CI)=0.7-20.2%) and the disease control rate after 2 months was 51.5%. The median progression-free survival was 2.93 months. Febrile neutropenia was observed in only two patients.
Conclusion:
The primary endpoint was not met in this study. However, weekly amrubicin achieved a high disease control rate and good tolerability.
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