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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
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Iron Overload in Children with Leukemia Receiving Multiple Blood Transfusions
Manjusha Nair1, Vijayalakshmi Kuttath2, Amita Radhakrishnan Nair2
1Department of Pediatrics, Regional Cancer Center, Trivandrum, Kerala, India. Correspondence to: Dr Manjusha Nair, PRA-19, Prasanth, Pathirappally Road, Poojappura PO, Trivandrum, Kerala, India. drmanjushanair@gmail.com.
Indian Pediatrics
|December 28, 2018
Summary
A quarter of pediatric leukemia patients experience iron overload post-treatment. High blood transfusion volumes are a key factor, necessitating monitoring for potential chelation therapy.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Chemistry
Background:
- Blood transfusions are common in pediatric leukemia treatment.
- Iron accumulation can occur due to repeated transfusions.
- Monitoring iron levels is crucial for patient outcomes.
Purpose of the Study:
- To determine the prevalence of iron overload in pediatric leukemia survivors.
- To identify factors contributing to iron overload.
- To assess the impact of transfusions on iron burden.
Main Methods:
- Serum ferritin and iron levels were measured in 66 children (age 1-14) post-leukemia treatment.
- Total blood transfusion volume was quantified for each patient.
- Transfusional iron overload was defined as serum ferritin >1000 ng/mL.
Main Results:
- 83.3% of patients received red blood cell transfusions.
- 24.2% of patients showed evidence of transfusional iron overload.
- Higher transfused volume (>100 mL/kg) and treatment intensity were significant predictors of iron overload.
Conclusions:
- Iron overload affects a significant portion of pediatric leukemia patients post-treatment.
- Monitoring iron levels is essential for these patients.
- Further follow-up is needed to guide chelation therapy decisions.
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