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Growth Patterns in Small for Gestational Age Babies and Correlation with Insulin-like Growth Factor-1 Levels

Deepika Rustogi1, Sangeeta Yadav2, Siddarth Ramji3

  • 1Department of Pediatrics,Maulana Azad Medical College (University of Delhi), New Delhi, India.

Indian Pediatrics
|December 28, 2018
PubMed

Insights

Most Small for Gestational Age babies experience catch-up growth by 18 months, with higher Insulin-like Growth Factor-1 (IGF-1) levels correlating positively with this growth. This suggests IGF-1 is a key indicator in monitoring SGA infant development.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Neonatology

Background:

  • Small for Gestational Age (SGA) infants often face growth challenges.
  • Insulin-like Growth Factor-1 (IGF-1) plays a crucial role in childhood growth.
  • Understanding factors influencing catch-up growth in SGA is vital for early intervention.

Purpose of the Study:

  • To investigate the correlation between catch-up growth and Insulin-like Growth Factor-1 (IGF-1) levels in infants born Small for Gestational Age (SGA).
  • To assess the prevalence of catch-up growth in SGA infants by 18 months of age.

Main Methods:

  • Fifty full-term SGA infants aged 12-18 months were enrolled.
  • Catch-up growth was defined as a gain in weight and/or length Standard Deviation Score (SDS) >0.67.
  • IGF-1 levels were measured using ELISA post-glucose load and correlated with growth parameters.

Main Results:

  • Catch-up growth was observed in 60% of the SGA infants by 18 months.
  • IGF-1 levels were significantly higher in infants achieving catch-up growth compared to those who did not.
  • A positive correlation was found between IGF-1 levels and both weight and length catch-up.

Conclusions:

  • The majority of SGA infants demonstrate catch-up growth by 18 months.
  • Elevated IGF-1 levels are associated with successful catch-up growth in SGA infants.
  • IGF-1 may serve as a valuable biomarker for monitoring growth in SGA populations.
Abstract

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