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Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Xiaohua Pei1, Shuyuan Lai1, Xianglan He1

  • 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China, zhaoweihongny@njmu.edu.cn.

Clinical Interventions in Aging
|December 28, 2018
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) is highly prevalent in maintenance hemodialysis (MHD) patients. Risk factors like age and comorbidities contribute, but MCI severity remained stable over six months in this study.

Area of Science:

  • Nephrology
  • Neurology
  • Geriatrics

Background:

  • Mild cognitive impairment (MCI) is understudied in maintenance hemodialysis (MHD) patients.
  • MHD patients represent a unique population with potential cognitive risks.

Purpose of the Study:

  • To determine the prevalence of MCI in MHD patients.
  • To identify risk factors associated with MCI in this cohort.
  • To observe the progression of MCI over a six-month period.

Main Methods:

  • Cognitive function assessed using Mini-Mental State Examination and Montreal Cognitive Assessment.
  • Sixty-four MHD patients with >3 months dialysis history were enrolled.
  • Comparison made with 54 general subjects.

Main Results:

  • MCI prevalence was significantly higher in MHD patients (60.9%) than the general population (29.6%).
  • MCI correlated with age, comorbidities, education, uric acid, albumin, and blood pressure.
  • MCI prevalence and severity were stable in MHD patients over six months.

Conclusions:

  • Maintenance hemodialysis patients exhibit a high prevalence of MCI.
  • Multiple factors influence MCI incidence and progression in MHD patients.
  • This population warrants increased clinical attention for cognitive health.
Keywords:
Mini-Mental State ExaminationMontreal Cognitive Assessmentdementiaend stage renal disease

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