Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.5K

Factors associated with carotid intima-media thickness in patients on maintenance hemodialysis

Ra Tuty Kuswardhani1, Ketut Gede Wiradharma2, Yenny Kandarini3

  • 1Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Indonesia, tutykuswardhani@yahoo.com.

International Journal of General Medicine
|December 28, 2018
PubMed

Insights

Carotid intima-media thickness (CIMT) is higher in hemodialysis patients with cardiovascular disease and in men. Age is the most significant factor influencing CIMT in this population.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Medical Imaging

Background:

  • Cardiovascular disease is a major complication for patients undergoing maintenance hemodialysis (mHD).
  • Carotid intima-media thickness (CIMT) is a subclinical marker of atherosclerosis and a predictor of cardiovascular events.
  • Understanding factors associated with CIMT in mHD patients is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association between carotid intima-media thickness (CIMT) and various clinical and biochemical parameters in patients receiving maintenance hemodialysis (mHD).

Main Methods:

  • A cross-sectional study involving 68 mHD patients (41 men, 27 women).
  • Carotid intima-media thickness (CIMT) was measured using B-mode ultrasonography with a 7.5 MHz linear transducer.
  • Statistical analysis included correlation and multiple linear regression to identify determinants of CIMT.

Main Results:

  • CIMT was significantly higher in patients with cardiovascular disease (CVD) compared to those without (0.7288 vs 0.6494 mm, P=0.026).
  • Men exhibited higher CIMT than women (0.7056 vs 0.6141 mm, P=0.003).
  • CIMT showed correlations with age, plasma albumin, serum phosphate, calcium-phosphate product, and high-sensitivity C-reactive protein. However, only age remained a significant independent predictor of CIMT (β=0.452, P<0.001) after multiple regression analysis.

Conclusions:

  • Patients on maintenance hemodialysis with cardiovascular disease and male patients have increased carotid intima-media thickness.
  • Factors such as older age, elevated high-sensitivity C-reactive protein, and lower levels of albumin, phosphate, and calcium-phosphate product are associated with higher CIMT.
  • Age is identified as the most critical determinant of CIMT in the mHD population, highlighting its importance in assessing atherosclerosis risk.
Abstract

Keywords:
agecarotid intima-media thicknesshemodialysis

More Related Videos

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.6K
A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

681

Related Concept Videos

Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
323
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.7K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
815
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
874
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
511