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Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study

Sarah El-Heis1, Sarah R Crozier1, Eugene Healy2

  • 1Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK, kmg@mrc.soton.ac.uk.

Clinical Epidemiology
|December 28, 2018
PubMed

Insights

Infants with atopic eczema show altered fetal growth patterns, including reduced linear growth before symptoms appear. This suggests growth faltering precedes the clinical onset of eczema and its treatment.

Area of Science:

  • Pediatrics
  • Dermatology
  • Human Growth and Development

Background:

  • Infants with atopic eczema face increased risks of impaired growth.
  • The origins of growth impairment in atopic eczema are not fully understood.

Purpose of the Study:

  • To investigate fetal and infant growth patterns in relation to infantile atopic eczema.
  • To determine if growth alterations precede the clinical manifestation of atopic eczema.

Main Methods:

  • Utilized data from the UK Southampton Women's Survey, including 1,759 infants.
  • Collected anthropometric measurements from 11 weeks gestation to 12 months of age.
  • Assessed infantile atopic eczema using modified UK Working Party criteria.

Main Results:

  • Higher femur length and abdominal circumference at 34 weeks gestation were linked to reduced atopic eczema risk.
  • Increased head-to-abdominal circumference ratio indicated disproportionate growth and higher atopic eczema risk.
  • Lower linear growth velocities from 11 weeks gestation to 6 months were associated with atopic eczema.
  • Infants with atopic eczema showed larger early head circumference and abdominal growth faltering from 19 to 34 weeks gestation.

Conclusions:

  • Infants with atopic eczema exhibit altered fetal growth patterns, including in utero linear growth faltering.
  • Growth disturbances appear to precede the clinical onset of atopic eczema and any subsequent treatment.
Abstract

Keywords:
atopic eczemafetal growthinfant growth

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