Bone Metastases Pattern in Newly Diagnosed Metastatic Bladder Cancer: A Population-Based Study

Area of Science:

• Oncology
• Epidemiology
• Cancer Metastasis

Background:

• Bone metastases (BM) are a significant concern in bladder cancer (BC) patients.
• Understanding the incidence, risk, and prognostic factors of BM is crucial for improving patient outcomes.

Purpose of the Study:

• To estimate the incidence and survival rates of bone metastases in initial bladder cancer patients.
• To identify risk factors associated with the occurrence of bone metastases in bladder cancer.
• To determine prognostic factors influencing survival in bladder cancer patients with bone metastases.

Main Methods:

• Utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database (2010-2014).
• Employed multivariate logistic and Cox regression analyses for risk and prognostic factor identification.
• Performed Kaplan-Meier analysis with log-rank test for survival estimation.

Main Results:

• Identified 1,223 (1.39%) bladder cancer patients with de novo bone metastases.
• Risk factors for BM include advanced age, black race, unmarried status, higher T/N stage, poor differentiation, and other metastases (lung, liver, brain).
• Median survival for BC patients with BM was 4.0 months; advanced age, no surgery, and other metastases predicted worse survival.

Conclusions:

• Bone metastases dramatically decrease survival in bladder cancer patients.
• This study provides population-based insights into risk and prognostic factors for initial bladder cancer with BM.
• Findings can aid in predicting BM occurrence and developing individualized treatment plans.