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Safe use of systemic bevacizumab for respiratory recurrent papillomatosis in two children

Claudio Carnevale1, Luis Ferrán-De la Cierva2, Guillermo Til-Pérez1

  • 1Department of Otolaryngology-Head and Neck Surgery and Pediatric Department, Son Espases University Hospital, Palma de Mallorca, Spain.

The Laryngoscope
|December 28, 2018
PubMed

Insights

Systemic bevacizumab shows promise for treating aggressive recurrent respiratory papillomatosis in children. This treatment improved respiratory symptoms and quality of life with minimal side effects.

Area of Science:

  • Pediatric Otolaryngology
  • Medical Oncology

Background:

  • Recurrent respiratory papillomatosis (RRP) is a rare, aggressive childhood disease with severe respiratory consequences.
  • Current treatments for RRP lack proven efficacy, necessitating novel therapeutic approaches.

Observation:

  • Two children with severe, aggressive RRP were treated with systemic bevacizumab.
  • Treatment led to dramatic improvements in respiratory symptoms and overall quality of life.

Findings:

  • Systemic bevacizumab demonstrated significant efficacy in managing aggressive RRP.
  • The treatment was well-tolerated, with mild proteinuria as the only noted complication.

Implications:

  • Systemic bevacizumab represents a promising adjuvant therapy for pediatric aggressive RRP.
  • Further research is warranted to determine optimal dosing and treatment duration for bevacizumab in RRP.

Keywords:
Respiratory papillomatosislaryngeal papillomatosis

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