Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

7.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
7.3K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

3.8K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.8K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

4.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
4.9K
Functional Groups02:45

Functional Groups

88.5K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.5K
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.6K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Group Joint ICA (gjICA): A Method for Multimodal Fusion of Concurrent EEG and fMRI Data.

Human brain mapping·2026
Same author

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same author

Sensorimotor recovery and neuropathic pain reduction after remotely delivered cognitive multisensory rehabilitation or remotely delivered exercise in adults with spinal cord injury: a pilot clinical trial.

medRxiv : the preprint server for health sciences·2026
Same author

AI-associated delusions: terminology.

The lancet. Psychiatry·2026
Same author

Large-scale brain dynamics are organized by a directional coordination hierarchy.

bioRxiv : the preprint server for biology·2026
Same author

Largely Typical Neural Activation During Monetary Reward Receipt in People With Psychosis-Spectrum Disorders and First-Degree Relatives.

Schizophrenia bulletin·2026

Related Experiment Video

Updated: Jan 31, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K

Spatial dynamics within and between brain functional domains: A hierarchical approach to study time-varying brain

Armin Iraji1, Zening Fu1, Eswar Damaraju1

  • 1The Mind Research Network, Albuquerque, New Mexico.

Human Brain Mapping
|December 28, 2018
PubMed
Summary

This study introduces a new hierarchical model to analyze brain dynamics, revealing spatial and temporal patterns in functional domains. The approach identifies changes in brain activity and connectivity, offering new insights into the chronnectome.

Keywords:
brain dynamicfunctional domainfunctional modulehigh-order independent component analysisintrinsic activityresting state fMRIschizophreniaspatial domain statespatial dynamics

More Related Videos

Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K

Related Experiment Videos

Last Updated: Jan 31, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K
Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K

Area of Science:

  • Neuroscience
  • Brain Imaging
  • Systems Neuroscience

Background:

  • Resting-state fMRI analysis of time-varying brain activity and connectivity (chronnectome) is crucial in neuroscience.
  • Previous research primarily focused on temporal coupling among fixed spatial nodes or dominant pattern transitions.
  • A gap exists in capturing both spatial and temporal dynamics within functional brain architectures.

Purpose of the Study:

  • To introduce a novel hierarchical approach for analyzing spatiotemporal dynamics within functional domains (FDs) and functional modules (FMs).
  • To model the brain's hierarchical functional architecture with varying levels of granularity and dynamic behavior.
  • To investigate brain dynamics in healthy individuals and patients with schizophrenia.

Main Methods:

  • Utilized high-order spatial independent component analysis to identify functional units (regions with similar activity).
  • Constructed functional domains (FDs) from functional units to represent hierarchical brain architecture.
  • Calculated functional modules (FMs) from FDs to provide a comprehensive view of brain dynamics.

Main Results:

  • Highlighted significant spatial fluidity within FDs, showing a range of regional associations from strong coupling to decoupling.
  • Demonstrated that FMs effectively capture the dynamic interplay between different functional domains.
  • Observed transient reductions in functional activity and connectivity in schizophrenia patients, particularly in the subcortical domain.
  • Found that activity and connectivity differences provide complementary information, especially in networks like the default mode network.

Conclusions:

  • The proposed hierarchical model offers novel insights into the macroscale chronnectome by capturing spatiotemporal variations in functional domains.
  • This approach reveals dynamic changes previously hidden by existing methods.
  • The findings underscore the importance of considering both spatial and temporal dynamics for a comprehensive understanding of brain function and dysfunction.