Comparison of several commonly used detection indicators of cell senescence
Yuanyuan Xiao1, Yiyuan Zhang1, Fang Xiao1
1Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, PR China.
Abstract:
Cell senescence is the state of irreversible growth arrest that can be triggered by a variety of different cellular stresses. Currently, the commonly used detection indicators involved in the study of cell senescence include senescence-associated β-galactosidase, Clusterin, Telomeres/Telomerase, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, senescence marker protein-30, tumor suppressor genes p53 and p16, and other indicators such as Ki67 and decoy receptor 2. These indicators are widely used in the study of cell senescence, each with its own characteristics, advantages, and disadvantages. This review summarizes several commonly used cell senescence indicators and compares their accuracy, credibility, specificity, and the scope of their potential application.
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