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Recurrence of Basal Plate Myofibers, with Further Consideration of Pathogenesis

Debra S Heller1, Rachel Wyand2, Stewart Cramer2

  • 1a Pathology & Laboratory Medicine , Rutgers-New Jersey Medical School , Newark , New Jersey , USA.

Fetal and Pediatric Pathology
|December 28, 2018
PubMed
Abstract

Insights

Basal plate myofibers (BPMF) indicate morbid adherence with a 100% recurrence rate. This suggests a potential heritable factor, like protease inhibitor deficiency, may cause pre-delivery placental damage.

Area of Science:

  • Perinatology
  • Pathology

Background:

  • Basal plate myofibers (BPMF) are associated with morbidly adherent placentas.
  • Understanding BPMF recurrence and progression is crucial for clinical management.

Purpose of the Study:

  • To assess the recurrence and clinical progression of basal plate myofibers (BPMF).
  • To evaluate the diagnostic utility of BPMF screening.

Main Methods:

  • Retrospective analysis of 135 BPMF placentas over 5 years.
  • Comparison with 50 control placentas from 2009.
  • Histological examination including actin stains for diagnosis.

Main Results:

  • BPMF exhibited a 100% recurrence rate in patients with subsequent placentas.
  • Actin stains confirmed BPMF in 65% of cases, with 59% showing clinical signs of morbid adherence.
  • Nearly half of BPMF recurrences progressed, with 11% resulting in hysterectomy.

Conclusions:

  • Findings support screening for BPMF to identify potential morbid adherence.
  • The high recurrence rate suggests a possible heritable etiology, such as protease inhibitor deficiency.
  • BPMF may be linked to pre-delivery basal plate damage.
Keywords:
accretabasal plate myofibersmorbid adherenceplacenta

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