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Crystal structures of disordered Z-type helices.

S Karthik1, P K Mandal1, A Thirugnanasambandam1

  • 1a Centre of Advanced Study in Crystallography and Biophysics , University of Madras, Guindy Campus , Chennai , Tamil Nadu , India.

Nucleosides, Nucleotides & Nucleic Acids
|December 28, 2018
PubMed
Summary
This summary is machine-generated.

X-ray crystallography reveals left-handed Z-type helices in two alternating pyrimidine-purine DNA sequences. These structures exhibit unique

Keywords:
Decamer and tetradecamer sequenceX-ray CrystallographyZ-DNA discontinuous helices

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Area of Science:

  • Structural biology
  • Biochemistry
  • Crystallography

Background:

  • DNA can adopt various helical structures beyond the canonical B-form.
  • Left-handed Z-DNA helices are known for their alternating purine-pyrimidine sequences.

Purpose of the Study:

  • To determine the X-ray crystal structures of two specific alternating pyrimidine-purine DNA sequences.
  • To analyze the helical structures and packing arrangements of these DNA sequences.

Main Methods:

  • X-ray crystallography was used to obtain high-resolution structural data.
  • Analysis of the crystal structures to elucidate DNA conformation and intermolecular interactions.

Main Results:

  • The decamer d(CGCGTACGCG)2 and tetradecamer d(CGCGCGTACGCGCG)2 sequences were crystallized.
  • Both sequences adopted disordered, pseudo-continuous left-handed Z-type helical conformations.
  • The observed packing mode featured 'bundles of columns of helices' with novel variations.

Conclusions:

  • Alternating pyrimidine-purine sequences can form stable left-handed Z-DNA helices.
  • The crystal structures provide insights into DNA polymorphism and molecular recognition.
  • The unique packing arrangements highlight the diverse ways DNA molecules can organize in the solid state.