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Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis.

Min Joo Kim1, Shinje Moon2, Byung-Chul Oh3

  • 11 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Thyroid : Official Journal of the American Thyroid Association
|December 28, 2018
PubMed
Summary
This summary is machine-generated.

This meta-analysis found that exposure to diethylhexyl phthalate (DEHP) metabolites is linked to thyroid function disruption. DEHP metabolite levels correlated with changes in thyrotropin and total thyroxine, indicating a significant association with the hypothalamic-pituitary-thyroid axis.

Keywords:
diethylhexyl phthalateendocrine disruptorsthyroid hormones

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer found globally in humans.
  • Previous studies suggest DEHP may disrupt the hypothalamic-pituitary-thyroid (HPT) axis, but evidence remains inconclusive.
  • This meta-analysis investigates the association between DEHP exposure and human HPT axis function.

Purpose of the Study:

  • To comprehensively evaluate the association between DEHP exposure and thyroid function in humans.
  • To analyze the correlation between major DEHP metabolites and key thyroid hormones.
  • To determine the impact of DEHP metabolites on the hypothalamic-pituitary-thyroid axis.

Main Methods:

  • A systematic literature search was conducted across MEDLINE, EMBASE, and Web of Science.
  • Included studies quantified DEHP metabolites (MEHP, MEHHP, MEHP) and thyroid hormones (TSH, free T4, total T4).
  • Pearson's correlation coefficients were used to assess associations, with pooled analyses performed.

Main Results:

  • Thirteen studies were included in the meta-analysis.
  • Urinary monoethylhexyl phthalate (MEHP) and mono [2-ethyl-5-hydroxyhexyl] phthalate (MEHHP) showed a negative correlation with total thyroxine (T4).
  • Urinary mono (2-ethyl-5-oxohexyl) phthalate was positively correlated with thyrotropin.

Conclusions:

  • The meta-analysis indicates a significant association between DEHP metabolite exposure and HPT axis function.
  • DEHP exposure may impact thyroid hormone levels and regulation in humans.
  • Further research is warranted to understand the clinical implications of these findings.