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A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents

Jasmin1, Vikas Jaitak1

  • 1Laboratory of Natural Products, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda (Pb.) 151001, India.

Mini Reviews in Medicinal Chemistry
|December 28, 2018
PubMed

Insights

Developing new anti-diabetic drugs is crucial due to side effects of current therapies. Natural products, especially flavonoids, offer promising alternatives for diabetes treatment by targeting multiple disease pathways.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Endocrinology

Background:

  • Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia.
  • Key factors include insulin resistance, oxidative stress, obesity, and beta-cell dysfunction.
  • Current synthetic anti-diabetic drugs often present adverse side effects.

Purpose of the Study:

  • To explore natural products as a source of novel anti-diabetic agents.
  • To discuss therapeutic strategies targeting multiple pathways involved in diabetes.
  • To highlight flavonoids as promising lead compounds for anti-diabetic drug development.

Main Methods:

  • Literature review of anti-diabetic drug discovery.
  • Analysis of mechanisms of action for natural products.
  • Examination of structure-activity relationships of flavonoids.

Main Results:

  • Natural products offer a viable alternative to synthetic drugs.
  • Flavonoids exhibit diverse anti-diabetic properties through various mechanisms.
  • Targeting multiple pathways simultaneously enhances therapeutic potential.

Conclusions:

  • Flavonoids are promising candidates for developing new anti-diabetic drugs.
  • Natural product-based therapies warrant further investigation for diabetes management.
  • A multi-target approach is essential for effective diabetes treatment.
Keywords:
antidiabetic agentsdiabetes mellitusflavonoidsinsulininsulin resistanceβ-cells.

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