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Diabetes and heart transplantation.

M J Rhenman1, B Rhenman, T Icenogle

  • 1Department of Surgery, University of Arizona Health Sciences Center, Tucson 85724.

The Journal of Heart Transplantation
|September 1, 1988
PubMed
Summary
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Selected patients with diabetes mellitus can undergo successful heart transplantation. This study found no significant difference in survival rates between diabetic and nondiabetic heart transplant recipients.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Endocrinology

Background:

  • Diabetes mellitus has historically been considered a contraindication for heart transplantation.
  • Assessing the outcomes of heart transplantation in diabetic patients is crucial for expanding eligibility criteria.

Purpose of the Study:

  • To evaluate the survival rates and post-transplant complications in patients with diabetes mellitus undergoing heart transplantation.
  • To determine if diabetes mellitus is a significant contraindication for heart transplantation.

Main Methods:

  • A retrospective comparison of 9 diabetic patients and 57 nondiabetic patients who underwent heart transplantation between June 1985 and December 1987.
  • Analysis of actuarial survival, rejection episodes, and infection rates in both groups.

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  • Standard immunosuppression protocols including cyclosporine, azathioprine, and prednisone were used.

    • Main Results:

    • Actuarial survival rates were 100% for diabetic patients and 97.7% for nondiabetic patients at the study's end.
    • No significant difference in survival was observed between the two groups.
    • Diabetic patients showed a trend towards more frequent rejection episodes and fewer infections.

    Conclusions:

    • Diabetes mellitus is not an absolute contraindication for heart transplantation in selected patients.
    • Successful outcomes are achievable in diabetic heart transplant recipients, with survival comparable to nondiabetic patients.
    • Careful patient selection and management are essential for optimizing results in diabetic heart transplant candidates.