Related Experiment Video
Updated: Jan 31, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
1.2K
Neoadjuvant Treatments for Advanced Resectable Melanoma
1Department of Surgery, Emory University, Atlanta, Georgia.
Journal of Surgical Oncology
|December 28, 2018
Summary
Neoadjuvant therapy, including immunotherapy and targeted therapy, shows improved survival for advanced melanoma patients before surgery. Research continues to advance these promising treatment options for resectable disease.
Area of Science:
- Oncology
- Melanoma Research
Background:
- Neoadjuvant therapy is a promising treatment for resectable advanced-stage melanoma.
- Treatment paradigms have shifted from traditional chemotherapy to include biochemotherapy, immunotherapy, and targeted therapy.
Purpose of the Study:
- To review the evolving landscape of neoadjuvant therapies for resectable advanced-stage melanoma.
- To highlight the benefits of novel neoadjuvant treatments over immediate surgical intervention.
Main Methods:
- Review of current literature and clinical trial data on neoadjuvant treatments for melanoma.
- Comparative analysis of survival outcomes between neoadjuvant therapy and upfront surgery.
Main Results:
- Neoadjuvant therapies, including biochemotherapy, immunotherapy, and targeted therapy, demonstrate improved progression-free survival and melanoma-specific survival.
- These novel treatments offer better outcomes compared to proceeding directly to surgery.
Conclusions:
- Neoadjuvant therapy represents a significant advancement in managing resectable advanced-stage melanoma.
- Ongoing clinical trials are crucial for further optimizing treatment strategies and improving patient outcomes.
Related Concept Videos
02:22Overview of Advanced Functional Groups
29.8K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.8K
00:56Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
01:08Sample Preparation for Analysis: Advanced Techniques
1.4K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.4K
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
539
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
539
01:27Open Angle Glaucoma: Treatment
996
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
996
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K