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Migraine Progression: A Systematic Review.

Dawn C Buse1, Jacob D Greisman2, Khosrow Baigi3

  • 1Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

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Summary
This summary is machine-generated.

Migraine progression to chronic forms is linked to increased headache frequency, depression, and medication overuse. These modifiable factors offer potential targets for preventing chronic migraine (CM).

Keywords:
chronic daily headachechronic migrainechronificationmigraineprogressiontransformation

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Migraine is a common neurological disorder with episodic and chronic forms.
  • Understanding factors predicting the transition from episodic to chronic migraine (CM) is crucial for prevention and treatment.
  • This review focuses on identifying and evaluating risk factors for new-onset CM.

Purpose of the Study:

  • To systematically review studies identifying risk factors for new-onset chronic migraine (CM) or related chronic headache disorders.
  • To synthesize evidence on modifiable and non-modifiable risk factors for migraine progression.

Main Methods:

  • Systematic review of English-language literature published before March 2018, searching PubMed.
  • Inclusion of longitudinal and case-control studies.
  • Qualitative synthesis and strength-of-evidence assessment using modified Hill's criteria.

Main Results:

  • Seventeen studies met inclusion criteria; evidence strength varied from fair to strong.
  • Strongest evidence supports increased headache day frequency, depression, and medication overuse as key risk factors.
  • Risk factors for new-onset CM in children and adolescents were similar to adults.

Conclusions:

  • Increased headache frequency, depression, and medication overuse are significant, potentially modifiable risk factors for chronic migraine.
  • These modifiable factors represent potential targets for interventions to prevent migraine progression.
  • Further research should explore interventions and refine understanding of migraine progression mechanisms.