Recent Advances in Nanozyme Research

Area of Science:

• Nanotechnology and Materials Science
• Biochemistry and Enzymology
• Computational Chemistry

Background:

• Nanozymes are emerging artificial enzymes with superior catalytic activity, stability, and cost-effectiveness.
• Their unique nanomaterial properties bridge nanotechnology and biology, driving research in diverse fields.
• Limited understanding of experimental phenomena and mechanisms hinders nanozyme development and application.

Purpose of the Study:

• To review experimental and computational research progress on nanozymes over the past decade.
• To highlight the development of new nanozymes mimicking various enzyme types and their applications.
• To discuss the catalytic mechanisms elucidated by experimental and theoretical studies and future computational challenges.

Main Methods:

• Review of experimental findings on nanozyme synthesis, structure-property relationships, and applications.
• Analysis of computational studies investigating nanozyme catalytic mechanisms.
• Synthesis of experimental and theoretical insights to identify research gaps and future directions.

Main Results:

• Overview of diverse nanozyme applications, including biosensing, bioimaging, therapeutics, and environmental remediation.
• Summary of proposed catalytic mechanisms for various nanozymes, supported by experimental and computational data.
• Identification of key challenges and opportunities for computational research in advancing nanozyme technology.

Conclusions:

• Nanozymes represent a promising class of artificial enzymes with broad applicability.
• Integrating experimental and computational approaches is crucial for understanding nanozyme mechanisms and optimizing their design.
• Future research should focus on advanced computational methods to accelerate nanozyme discovery and application.