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Motoric cognitive risk syndrome and mortality: results from the EPIDOS cohort
O Beauchet1,2,3,4, H Sekhon1,3,5, C P Launay6
1Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.
Background And Purpose:
Cognitive impairment, slow walking speed and motoric cognitive risk syndrome (MCR) have separately been associated with an increased risk for mortality in the short term. The aim of the study was to examine the association of MCR and its components [i.e. subjective cognitive complaint (SCC) and slow walking speed] with short-, medium- and long-term mortality in older community-dwellers.
Methods:
In all, 3778 participants from the Epidémiologie de l'Ostéoporose (EPIDOS) study were selected. MCR was defined as the combination of slow walking speed and SCC in participants without major neurocognitive disorders. Deaths were prospectively recorded using mail, phone calls, questionnaires and/or the French national death registry at 5, 10, 15 and 19 (end of follow-up period) years.
Results:
Over the follow-up of 19 years, 80.5% (n = 3043) participants died. Slow walking speed and MCR were associated with mortality [hazard ratio (HR) 1.20 with P = 0.004 for slow walking speed and HR = 1.26 with P = 0.002 for MCR at 10 years; HR = 1.27 with P ≤ 0.001 for slow walking speed and HR = 1.22 with P = 0.001 for MCR at 15 years; HR = 1.41 with P ≤ 0.001 at 19 years for slow walking speed and MCR]. There was no association between SCC and mortality. Kaplan-Meier distributions of mortality showed that participants with MCR and slow walking speed died earlier compared to healthy participants and those with SCC (P < 0.001).
Conclusions:
Slow walking speed and MCR were associated with an increased risk for mortality at the medium and long term, whereas no association was found with SCC.
Insights
Motoric cognitive risk syndrome (MCR) and slow walking speed are linked to increased mortality risk in older adults over the long term. Subjective cognitive complaints alone did not show an association with mortality.
Area of Science:
- Gerontology
- Neurology
- Public Health
Background:
- Motoric cognitive risk syndrome (MCR) and its components, slow walking speed, and subjective cognitive complaints (SCC), are individually linked to short-term mortality.
- The relationship between MCR and long-term mortality requires further investigation.
Purpose of the Study:
- To investigate the association between MCR and its components (SCC and slow walking speed) and short-, medium-, and long-term mortality in older community-dwelling adults.
Main Methods:
- The study included 3778 participants from the Epidémiologie de l'Ostéoporose (EPIDOS) study.
- MCR was defined as the combination of slow walking speed and SCC in individuals without major neurocognitive disorders.
- Mortality data were prospectively collected over 19 years.
Main Results:
- Over 19 years, 80.5% of participants died.
- Both slow walking speed (HR 1.41, P < 0.001) and MCR (HR 1.41, P < 0.001) were significantly associated with increased mortality at 19 years.
- No significant association was found between SCC and mortality.
Conclusions:
- Slow walking speed and MCR are associated with increased medium- and long-term mortality risk in older adults.
- Subjective cognitive complaints alone are not associated with mortality risk.
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