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Correcting standardized expiratory flows for prematurity in ex-preterm survivors-Is it necessary?

Lex W Doyle1,2,3,4, Jeanie L Y Cheong1,2,4, Sarath Ranganathan3,5,6

  • 1Neonatal Services, Royal Women's Hospital, Melbourne, Australia.

Pediatric Pulmonology
|December 28, 2018
PubMed

Insights

Correcting expiratory flow rates for prematurity is not necessary in clinical practice or research. This study found minimal impact on standardized values across childhood and adulthood.

Area of Science:

  • Pulmonary physiology
  • Pediatric respiratory health

Background:

  • Standardized lung function tests are crucial for assessing respiratory health.
  • Prematurity can influence lung development and may affect airflow measurements.
  • The necessity of correcting for prematurity in lung function studies across different age groups remains unclear.

Purpose of the Study:

  • To evaluate the impact of correcting for prematurity on standardized expiratory flow rates.
  • To analyze these effects in individuals aged 5 to 70 years.
  • To determine if age correction for prematurity is required in clinical and research settings.

Main Methods:

  • A theoretical model was used to simulate z-score variations in expiratory flows, adjusting for prematurity and age.
  • The model analyzed age ranges from 5 to 16.9 years and 16 to 70 years for both sexes.
  • A clinical comparison involved extremely preterm survivors and term-born controls at 8 and 18 years of age.

Main Results:

  • Theoretical models showed z-scores generally declining through adolescence and rising in later life.
  • The maximum difference in z-scores due to prematurity correction was approximately -0.09 SD for forced vital capacity in early teens.
  • Clinical data indicated a maximum gap of 0.06 SD in forced vital capacity at age 8 when prematurity was not corrected.

Conclusions:

  • Correction for prematurity does not significantly alter standardized expiratory flow rates.
  • Age correction for prematurity is deemed unnecessary for both clinical practice and research in respiratory airflow studies.
  • Findings support using uncorrected age in longitudinal and cross-sectional studies of lung function.
Abstract

Keywords:
correction for prematurityinfantlung function

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