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Aliphatic polyesters and cellulose-based polymers for controlled release applications.

R K Chang1, J C Price

  • 1Schering Research, Miami, FL 33169.

Journal of Biomaterials Applications
|July 1, 1988
PubMed
Summary
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This review covers drug delivery system fabrication technologies. It highlights biodegradable polyesters for injections and cellulose polymers for oral use, focusing on controlled drug release applications.

Area of Science:

  • Polymer science
  • Materials science
  • Pharmaceutical technology

Background:

  • Drug delivery systems are crucial for effective therapeutic outcomes.
  • Controlled drug release is essential for optimizing medication efficacy and patient compliance.
  • Advances in polymer science offer versatile solutions for drug delivery challenges.

Purpose of the Study:

  • To review general fabrication technologies for drug delivery systems.
  • To present commonly used polymers for drug delivery, specifically biodegradable aliphatic polyesters and cellulose-based polymers.
  • To illustrate the properties and applications of these polymers in controlling drug release.

Main Methods:

  • Review of existing literature on drug delivery system fabrication.

Related Experiment Videos

  • Selection and presentation of examples of biodegradable aliphatic polyesters.
  • Selection and presentation of examples of cellulose-based polymers.

    • Main Results:

    • Biodegradable aliphatic polyesters are suitable for parenteral administration, offering controlled release profiles.
    • Cellulose-based polymers are effective for oral drug delivery, enabling tunable release characteristics.
    • Various fabrication technologies enable the precise engineering of these polymeric drug delivery systems.

    Conclusions:

    • Biodegradable polyesters and cellulose-based polymers represent key materials for advanced drug delivery systems.
    • The choice of polymer and fabrication technology significantly impacts drug release kinetics and therapeutic effectiveness.
    • Further research into polymer properties and fabrication methods will continue to enhance drug delivery system design.