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Updated: Jan 31, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
[Antimycotic therapy impact on oral mucosa Candida species composition in HIV-infected patients]
Yu S Filina1, A I Shatokhin2, E V Volchkova3
1Infectious Diseases Clinical Hospital #2, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Research Objectives:
the analysis of a specific and strains drift of Candida in HIV/AIDS patients with oropharyngeal candidiasis and the analysis of Candida sensitivity dynamics to reference antimycotic drugs. The study comprised 49 HIV-infected patients aged 20-69 years. The study revealed candidiasis treatment provides specific and strains drift of Candida. Eradication of fluconazole sensitive C. albicans leads to growth of more resistant strains (C. glabratae, krusei, tropicalis) thus lowering antimycotic therapy efficacy. The efficacy improvement requires selective approach to candidiasis treatment with azol agents.
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